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y integrating high-quality DDR biomarkers with advanced research platforms, including immunohistochemistry (IHC), immunofluorescence (IF), Western blot, flow cytometry, and multiplex spatial analysis, our antibody solutions support detailed characterization of cancer genome maintenance programs and treatment-associated molecular changes.
Tumor Suppressor & DNA Damage Repair Biomarker Antibody Portfolio
——Comprehensive Solutions for Genome Stability Profiling, DNA Repair Pathway Analysis, and Cancer Mechanism Discovery
Comprehensive characterization of DNA damage responses requires integrated analysis of damage sensors, repair enzymes, checkpoint regulators, and tumor suppressor networks.
Our antibody portfolio supports investigation of major DNA repair pathways and cancer-associated genome instability mechanisms.
Research Focus | Representative Biomarkers | Research Applications |
DNA Damage Recognition & Checkpoint Activation | ATM, ATR, Chk1, Chk2, γH2AX, Histone H2A.X | Detection of DNA damage signaling, replication stress, and checkpoint activation |
Tumor Suppressor Pathway Regulation | p53, p21/CDKN1A, p16/CDKN2A, RB | Analysis of growth arrest, apoptosis, senescence, and tumor suppression mechanisms |
Base Excision Repair (BER) | PARP1, APEX1 (APE1), POLB, XRCC1, LIG3 | Investigation of oxidative DNA damage repair and PARP-dependent repair pathways |
Double-Strand Break Repair — NHEJ | RKDC (DNA-PKcs), XRCC6 (Ku70), XRCC5 (Ku80), XRCC4, LIG4 | Characterization of DNA end recognition and classical NHEJ repair activity |
Double-Strand Break Repair — Homologous Recombination (HR) | BRCA1, BRCA2, RAD51, RAD52, RAD54L, XRCC2, XRCC3, RAD51C, RAD51D | Evaluation of HR repair competency and synthetic lethality mechanisms |
MRN DNA Damage Sensor Complex | MRE11, RAD50, NBS1 | Analysis of early double-strand break recognition and ATM pathway activation |
Nucleotide Excision Repair (NER) | ERCC1, XPA, XPC, ERCC2 (XPD), ERCC4 (XPF), ERCC5 (XPG) | Investigation of bulky DNA adduct repair and chemotherapy resistance |
Mismatch Repair (MMR) | MLH1, MSH2, MSH6, PMS2 | Microsatellite instability (MSI) analysis and cancer classification |
Fanconi Anemia Crosslink Repair | FANCA, FANCD2, FANCI, FANCL, FANCM | Study of DNA interstrand crosslink repair and platinum drug sensitivity |
Telomere Protection & Genome Stability | TRF1, TRF2,TERT, DKC1, POT1, TINF2, ACD , TERF2IP | Investigation of cellular immortalization and chromosome-end maintenance |
Core Tumor Suppressor & DNA Repair Targets