2.2 Genome & Classification

The S. suis genome is a circular chromosome of approximately 2.0–2.1 Mb. Through multilocus sequence typing (MLST), over 4,200 sequence types (STs) have been identified to date, reflecting the extremely high genetic variability of this bacterium, which complicates the development of broadly protective vaccines. S. suis produces over 70 virulence factors, several of which have been extensively studied as potential vaccine targets.

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~~clusters for quick removal of cell layers~~. The one-piece design and chiseled blade provide improved control while
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5. References

Brangsch, H., Berens, C., Fuchs, S., et al. (2026). Genome characteristics and type IV effector protein repertoire of Coxiella burnetii depend rather on Genomic Groups than on host species. BMC microbiology, 26(1), 393.
Yuan, J., Zhang, Y., Song, L., et al. (2025). Modulation of host cell pathways by Coxiella burnetii Dot/Icm effectors. mLife, 4(6), 579–598.
Bird, L. E., Xu, B., Hobbs, A. D., et al. (2025). Coxiella burnetii manipulates the lysosomal protease cathepsin B to facilitate intracellular success. Nature communications, 16(1), 3844.
Arunima, A., Niyakan, S., Butler, S. M., et al. (2025). CYP1B1-AS1 regulates CYP1B1 to promote Coxiella burnetii pathogenesis by inhibiting ROS and host cell death. Nature communications, 16(1), 7493.
Palanisamy, R., Zhang, Y., Zhang, G. (2024). Role of Type 4B Secretion System Protein, IcmE, in the Pathogenesis of Coxiella burnetii. Pathogens (Basel, Switzerland), 13(5), 405.

2.3 What Are S. suis Virulence Factors？

The virulence factors of S. suis primarily include:

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2.3.1 Dynamic Regulation of Capsular Polysaccharide (CPS)

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