U-Blot® Presenilin 2 Rabbit mAb

Background：Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1 or PSEN2) or the amyloid precursor protein (APP) . These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains) . Presenilins are postulated to regulate APP processing through their effects on gamma-secretase , an enzyme that cleaves APP. Also , it is thought that the presenilins are involved in the cleavage of the Notch receptor such that , they either directly regulate gamma-secretase activity , or themselves act are protease enzymes. Two alternatively spliced transcript variants encoding different isoforms of PSEN2 have been identified. [provided by RefSeq , Jul 2008] ,