U-Blot® EphB3 Rabbit mAb

Background：Ephrin receptors and their ligands , the ephrins , mediate numerous developmental processes , particularly in the nervous system. Based on their structures and sequence relationships , ephrins are divided into the ephrin-A (EFNA) class , which are anchored to the membrane by a glycosylphosphatidylinositol linkage , and the ephrin-B (EFNB) class , which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B family members. [provided by RefSeq , Mar 2010] ,