U-Blot® 14 3 3σ Rabbit mAb

Background：function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners , usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17 , regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. ,function:p53-regulated inhibitor of G2/M progression. ,similarity:Belongs to the 14-3-3 family. ,subcellular location:May be secreted by a non-classical secretory pathway. ,subunit:Homodimer. Interacts with KRT17 (By similarity) . Found in a complex with XPO7 , EIF4A1 , ARHGAP1 , VPS26A , VPS29 , VPS35 and SFN. ,tissue specificity:Present mainly in tissues enriched in stratified squamous keratinising epithelium. ,