U-Blot® TRADD Rabbit mAb

Background：The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2 , reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2 , and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1 , and is involved in the Fas-induced cell death pathway. [provided by RefSeq , Jul 2008] ,