- Target
- ACTN4
- Reactivity
- Human,Mouse,Rat
- Application
- WB,IHC,IF,IP,ELISA
- MW(Calculated)
- 105kD
- MW(Observed)
- 105kD
- Host Species
- Rabbit
- Isotype
- IgG, Kappa
- Conjugate/Modification
- Unmodified
- Modification site
- --
- Recommended Dilution Ratio
- IHC 1:200-1:1000;WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;IP 1:50-1:200
- Form
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
- Source
- --
- Purification
- Recombinant Antibody expressed in animal component-free (ACF) media, purified via Protein A affinity chromatography.
- Purity
- --
- storageCondition
- -15°C to -25°C/1 year (Do not lower than -25°C)
- Concentration
- --
- Clonality
- Monoclonal
- Clone No.
- PT1920R
- Immunogen
- --
- Sequence
- --
- Specificity
- Endogenous
- Gene Name
- ACTN4
- Protein Name
- Alpha-actinin-4 (F-actin cross-linking protein) (Non-muscle alpha-actinin 4)
- Other Name
- --
- Organism-1
- Human
- Gene ID-1
- 81
- SwissProt-1
- O43707
- Organism-2
- Mouse
- Gene ID-2
- 60595
- SwissProt-2
- P57780
- Organism-3
- Rat
- Gene ID-3
- 63836
- SwissProt-3
- Q9QXQ0
- Organism-4
- --
- gene ID-4
- --
- SwissProt-4
- --
- Cellular Localization
- Nucleus . Cytoplasm . Cell junction . Cytoplasm , cytoskeleton , stress fiber . Cytoplasm , perinuclear region . Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Expressed in the perinuclear rim and manchette structure in early elongating spermatids during spermiogenesis (By similarity) . Nuclear translocation can be induced by the PI3 kinase inhibitor wortmannin or by cytochalasin D. Exclusively localized in the nucleus in a limited number of cell lines (breast cancer cell line MCF-7 , oral floor cancer IMC-2 , and bladder cancer KU-7) . .