U-Blot® ROCK2 Rabbit mAb

U-Blot® ROCK2 Rabbit mAb
U-Blot® ROCK2 Rabbit mAb
$268.00
Size:50μL
SKU: WR4995-50

Catalog No.: WR4995

Specification: 50μL/100μL

Stock: In stock

U-Blot® ROCK2 Rabbit mAb Learn more

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Product information

Product detailsSpecificationsQ & AEducation

Background：The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho. [provided by RefSeq, Jul 2008],

Product Overview

Catalog No.
WR4995
SKU
WR4995-50
Category
Rabbit mAbs
Product Type
Other
Size
50μL/100μL
Stock Status
In stock
Available Stock
20
Minimum Order Quantity
1

Storage & Compliance

Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only
Yes

Additional Specifications

Target
ROCK2
Reactivity
Human,Mouse,Rat
Application
WB,IF,ELISA
MW(Calculated)
161kD
MW(Observed)
161kD
Host Species
Rabbit
Isotype
IgG,Kappa
Conjugate/Modification
Unmodified
Modification site
--
Recommended Dilution Ratio
WB 1:2000-1:10000;IF 1:200-1:1000;ELISA 1:5000-1:20000;
Form
PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
Source
--
Purification
Protein A
Purity
--
storageCondition
-15°C to -25°C/1 year(Do not lower than -25°C)
Concentration
--
Clonality
Monoclonal
Clone No.
PT1227R
Immunogen
--
Sequence
--
Specificity
Endogenous
Gene Name
ROCK2 KIAA0619
Protein Name
Rho-associated protein kinase 2
Other Name
ROCK2;KIAA0619;Rho-associated protein kinase 2;Rho kinase 2;Rho-associated;coiled-coil-containing protein kinase 2;Rho-associated, coiled-coil-containing protein kinase II;ROCK-II;p164 ROCK-2
Organism-1
Human
Gene ID-1
9475
SwissProt-1
O75116
Organism-2
Mouse
Gene ID-2
19878
SwissProt-2
P70336
Organism-3
Rat
Gene ID-3
25537
SwissProt-3
Q62868
Organism-4
--
gene ID-4
--
SwissProt-4
--
Cellular Localization
Catalytic activity:ATP + a protein = ADP + a phosphoprotein.,enzyme regulation:Activated by RHOA binding.,Function:Protein kinase that phosphorylates a large number of important signaling proteins, and thereby regulates the assembly of the actin cytoskeleton. Promotes formation of stress fibers and of focal adhesion complexes. Plays a role in smooth muscle contraction.,miscellaneous:Inhibited by Y-27632.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.,similarity:Contains 1 AGC-kinase C-terminal domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 phorbol-ester/DAG-type zinc finger.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 REM (Hr1) repeat.,subcellular location:Cytoplasmic, and associated with actin microfilaments and the plasma membrane.,subunit:Homodimer. Binds RHOA that has been activated by GTP binding. Binds IRS1, RHOB and RHOC.,

Tech Support

ucallm

01

Documents

Datasheet, COA, SDS, and protocol files can be requested from technical support.

02

Storage & Handling

Storage
-15°C to -25°C/1 year(Do not lower than -25°C)
06

Contact Support

Emailinfo@mail.ucallm.com

Phone+(1)-866-986-9598

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Keywords:Rabbit mAbs