Product information
Background:function:Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription.,similarity:Contains 3 PAH (paired amphipathic helix) repeats.,subunit:Interacts with FOXK1/MNF, MXI, MAD, NCOR1 and SAP30. Interaction with SDS3 enhances the interaction with HDAC1 to form a complex. Interacts with MAD3, MAD4, MAEL, REST and SETDB1 (By similarity). Interacts with HCFC1.,
Product Overview
- Catalog No.
- WP13297
- SKU
- WP13297-50
- Category
- Polyclonal antibodies
- Product Type
- Other
- Size
- 50μL/100μL
- Stock Status
- In stock
- Available Stock
- 20
- Minimum Order Quantity
- 1
Storage & Compliance
- Storage
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Research Use Only
- Yes
Additional Specifications
- Target
- Sin3B
- Reactivity
- Human,Mouse
- Application
- WB,ELISA,IHC
- MW(Calculated)
- --
- MW(Observed)
- 130kD
- Host Species
- Rabbit
- Isotype
- IgG
- Conjugate/Modification
- Unmodified
- Modification site
- --
- Recommended Dilution Ratio
- WB 1:500-2000;IHC 1:50-300;ELISA 1:2000-20000
- Form
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source
- --
- Purification
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Purity
- --
- storageCondition
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Concentration
- 1 mg/ml
- Clonality
- Polyclonal
- Clone No.
- --
- Immunogen
- The antiserum was produced against synthesized peptide derived from human SIN3B. AA range:221-270
- Sequence
- --
- Specificity
- Sin3B Polyclonal Antibody detects endogenous levels of Sin3B protein.
- Gene Name
- SIN3B
- Protein Name
- Paired amphipathic helix protein Sin3b
- Other Name
- SIN3B;KIAA0700;Paired amphipathic helix protein Sin3b;Histone deacetylase complex subunit Sin3b;Transcriptional corepressor Sin3b
- Organism-1
- Human
- Gene ID-1
- 23309
- SwissProt-1
- O75182
- Organism-2
- Mouse
- Gene ID-2
- --
- SwissProt-2
- Q62141
- Organism-3
- --
- Gene ID-3
- --
- SwissProt-3
- --
- Organism-4
- --
- gene ID-4
- --
- SwissProt-4
- --
- Cellular Localization
- Nucleus .
01
Documents
Datasheet, COA, SDS, and protocol files can be requested from technical support.
02
Storage & Handling
- Storage
- -15°C to -25°C/1 year(Do not lower than -25°C)