U-Blot® LRP1 Polyclonal Antibody

Name: U-Blot® LRP1 Polyclonal Antibody
SKU: WP13021
Availability: InStock

$268.00

Size:50μL

SKU: WP13021-50

Catalog No.: WP13021

Specification: 50μL/100μL

Stock: In stock

U-Blot® LRP1 Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015],

Product Overview

Catalog No.: WP13021
SKU: WP13021-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: LRP1
Reactivity: Human,Mouse
Application: WB,IHC,IF,ELISA
MW(Calculated): --
MW(Observed): 80kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:40000;IF 1:50-200
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: The antiserum was produced against synthesized peptide derived from human CD91. AA range:4486-4535
Sequence: --
Specificity: LRP1 Polyclonal Antibody detects endogenous levels of LRP1 protein.
Gene Name: LRP1
Protein Name: Prolow-density lipoprotein receptor-related protein 1
Other Name: LRP1;A2MR;APR;Prolow-density lipoprotein receptor-related protein 1;LRP-1;Alpha-2-macroglobulin receptor;A2MR;Apolipoprotein E receptor;APOER;CD antigen CD91
Organism-1: Human
Gene ID-1: 4035
SwissProt-1: Q07954
Organism-2: Mouse
Gene ID-2: 16971
SwissProt-2: Q91ZX7
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: [Low-density lipoprotein receptor-related protein 1 85 kDa subunit]: Cell membrane; Single-pass type I membrane protein. Membrane, coated pit.; [Low-density lipoprotein receptor-related protein 1 515 kDa subunit]: Cell membrane; Peripheral membrane protein; Extracellular side. Membrane, coated pit.; [Low-density lipoprotein receptor-related protein 1 intracellular domain]: Cytoplasm . Nucleus . After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus. .; Golgi outpost . Cytoplasm, cytoskeleton, microtubule organizing center . Localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, which shapes dendrite morphology by functioning as sites of acentrosomal microtubule nucleation. .