U-Blot® IL-1α Polyclonal Antibody

Name: U-Blot® IL-1α Polyclonal Antibody
SKU: WP12814
Availability: InStock

$268.00

Size:50μL

SKU: WP12814-50

Catalog No.: WP12814

Specification: 50μL/100μL

Stock: In stock

U-Blot® IL-1α Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008],

Product Overview

Catalog No.: WP12814
SKU: WP12814-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: IL-1α
Reactivity: Human,Mouse,Rat
Application: IHC,IF,ELISA
MW(Calculated): 31kD
MW(Observed): --
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: IHC 1:100-1:300;ELISA 1:10000;IF 1:50-200
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: The antiserum was produced against synthesized peptide derived from human IL-1alpha. AA range:8-57
Sequence: --
Specificity: IL-1α Polyclonal Antibody detects endogenous levels of IL-1α protein.
Gene Name: IL1A
Protein Name: Interleukin-1 alpha
Other Name: IL1A;IL1F1;Interleukin-1 alpha;IL-1 alpha;Hematopoietin-1
Organism-1: Human
Gene ID-1: 3552
SwissProt-1: P01583
Organism-2: Mouse
Gene ID-2: 16175
SwissProt-2: P01582
Organism-3: Rat
Gene ID-3: 24493
SwissProt-3: P16598
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cytoplasm . Secreted . The lack of a specific hydrophobic segment in the precursor sequence suggests that IL-1 is released by damaged cells or is secreted by a mechanism differing from that used for other secretory proteins. The secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). .