U-Blot® Centriolin Polyclonal Antibody

Name: U-Blot® Centriolin Polyclonal Antibody
SKU: WP11578
Availability: InStock

$268.00

Size:50μL

SKU: WP11578-50

Catalog No.: WP11578

Specification: 50μL/100μL

Stock: In stock

U-Blot® Centriolin Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：function:Necessary for centrosome duplication. Collaborates with CEP97, being involved in the suppression of a cilia assembly program. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2.,induction:Up-regulated during the transition from G1 to S phase of the cell cycle. The highest levels are observed in S phase, after which the levels decrease markedly.,PTM:Phosphorylated by CDKs.,subunit:Interacts with CALM1, CETN2 and CEP97.,tissue specificity:Highly expressed in testis. Detected at intermediate levels in spleen, thymus, prostate, small intestine, colon and peripheral blood leukocytes.,

Product Overview

Catalog No.: WP11578
SKU: WP11578-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: Centriolin
Reactivity: Human,Mouse
Application: IHC,IF,ELISA
MW(Calculated): 113kD
MW(Observed): --
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: IHC 1:100-1:300;ELISA 1:40000;IF 1:50-200
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: The antiserum was produced against synthesized peptide derived from human CEP110. AA range:850-900
Sequence: --
Specificity: Centriolin Polyclonal Antibody detects endogenous levels of Centriolin protein.
Gene Name: CCP110
Protein Name: Centriolar coiled-coil protein of 110 kDa
Other Name: CCP110;CEP110;CP110;KIAA0419;Centriolar coiled-coil protein of 110 kDa;Centrosomal protein of 110 kDa;CP110;Cep110
Organism-1: Human
Gene ID-1: 9738
SwissProt-1: O43303
Organism-2: Mouse
Gene ID-2: --
SwissProt-2: Q7TSH4
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, cilium basal body . Recruited early and then associates with the growing distal tips. Recruited to the mother centriole by KIF24 (PubMed:21620453). Removed from centrioles by TTBK2, leading to initiation of ciliogenesis and localizes only to the daughter centriole in ciliated cells. In cytotoxic T lymphocytes remains associated with the mother centriole during docking of the centrosome at the immunological synapse upon target contact (By similarity). Recruited at the distal end of the mother centriole by MPHOSPH9 (PubMed:30375385). .