U-Blot® Bub1 Polyclonal Antibody

Name: U-Blot® Bub1 Polyclonal Antibody
SKU: WP11326
Availability: InStock

$268.00

Size:50μL

SKU: WP11326-50

Catalog No.: WP11326

Specification: 50μL/100μL

Stock: In stock

U-Blot® Bub1 Polyclonal Antibody Learn more

Product details Specifications Q & A Education

Background：This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],

Product Overview

Catalog No.: WP11326
SKU: WP11326-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: Bub1
Reactivity: Human,Mouse
Application: IHC,IF,ELISA
MW(Calculated): 122kD
MW(Observed): --
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Unmodified
Modification site: --
Recommended Dilution Ratio: IHC 1:100-1:300;ELISA 1:10000;IF 1:50-200
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: The antiserum was produced against synthesized peptide derived from human BUB1. AA range:251-300
Sequence: --
Specificity: Bub1 Polyclonal Antibody detects endogenous levels of Bub1 protein.
Gene Name: BUB1
Protein Name: Mitotic checkpoint serine/threonine-protein kinase BUB1
Other Name: BUB1;BUB1L;Mitotic checkpoint serine/threonine-protein kinase BUB1;hBUB1;BUB1A
Organism-1: Human
Gene ID-1: 699
SwissProt-1: O43683
Organism-2: Mouse
Gene ID-2: 12235
SwissProt-2: O08901
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Nucleus. Chromosome, centromere, kinetochore. Nuclear in interphase cells. Accumulates gradually during G1 and S phase of the cell cycle, peaks at G2/M, and drops dramatically after mitosis. Localizes to the outer kinetochore. Kinetochore localization is required for normal mitotic timing and checkpoint response to spindle damage and occurs very early in prophase. AURKB, KNL1 and INCENP are required for kinetochore localization (By similarity). .