Product information
Background:This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012],
Product Overview
- Catalog No.
- WP1076
- SKU
- WP1076-50
- Category
- Polyclonal antibodies
- Product Type
- Other
- Size
- 50μL/100μL
- Stock Status
- In stock
- Available Stock
- 20
- Minimum Order Quantity
- 1
Storage & Compliance
- Storage
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Research Use Only
- Yes
Additional Specifications
- Target
- TOP1M
- Reactivity
- Human,Mouse,Rat
- Application
- WB,ELISA
- MW(Calculated)
- --
- MW(Observed)
- 66kD
- Host Species
- Rabbit
- Isotype
- IgG
- Conjugate/Modification
- Unmodified
- Modification site
- --
- Recommended Dilution Ratio
- WB 1:500-2000;ELISA 1:5000-20000
- Form
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
- Source
- --
- Purification
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Purity
- --
- storageCondition
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Concentration
- 1 mg/ml
- Clonality
- Polyclonal
- Clone No.
- --
- Immunogen
- Synthesized peptide derived from part region of human protein
- Sequence
- --
- Specificity
- TOP1M Polyclonal Antibody detects endogenous levels of protein.
- Gene Name
- TOP1MT
- Protein Name
- DNA topoisomerase I, mitochondrial (TOP1mt) (EC 5.99.1.2)
- Other Name
- --
- Organism-1
- Human
- Gene ID-1
- 116447
- SwissProt-1
- Q969P6
- Organism-2
- Mouse
- Gene ID-2
- --
- SwissProt-2
- Q8R4U6
- Organism-3
- Rat
- Gene ID-3
- --
- SwissProt-3
- Q6IM78
- Organism-4
- --
- gene ID-4
- --
- SwissProt-4
- --
- Cellular Localization
- Mitochondrion .
01
Documents
Datasheet, COA, SDS, and protocol files can be requested from technical support.
02
Storage & Handling
- Storage
- -15°C to -25°C/1 year(Do not lower than -25°C)