U-Blot® Smad1 (Phospho Ser214) rabbit pAb

Name: U-Blot® Smad1 (Phospho Ser214) rabbit pAb
SKU: WP10568
Availability: InStock

$288.00

Size:50μL

SKU: WP10568-50

Catalog No.: WP10568

Specification: 50μL/100μL

Stock: In stock

U-Blot® Smad1 (Phospho Ser214) rabbit pAb Learn more

Product details Specifications Q & A Education

Background：function:Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD).,PTM:Phosphorylated on serine by BMP type 1 receptor kinase.,PTM:Ubiquitin-mediated proteolysis by SMAD-specific E3 ubiquitin ligase SMURF1.,similarity:Belongs to the dwarfin/SMAD family.,similarity:Contains 1 MH1 (MAD homology 1) domain.,similarity:Contains 1 MH2 (MAD homology 2) domain.,subcellular location:Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4.,subunit:Interacts with HGS, NANOG and ZCCHC12 (By similarity). May form trimers with another SMAD1 and the co-SMAD SMAD4. Interacts with PEBP2-alpha subunit, CREB-binding protein (CBP), p300, SMURF1, SMURF2 and HOXC8. Associates with ZNF423 or ZNF521 in response to BMP2 leading to activate transcription of BMP target genes. Interacts with LBXCOR1.,tissue specificity:Ubiquitous. Highest expression seen in the heart and skeletal muscle.,

Product Overview

Catalog No.: WP10568
SKU: WP10568-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: Smad1
Reactivity: Human,Mouse,Rat
Application: WB,IHC
MW(Calculated): --
MW(Observed): 51kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: WB 1:500-2000;IHC 1:50-300
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: Synthesized peptide derived from human Smad1 (Phospho Ser214)
Sequence: --
Specificity: This antibody detects endogenous levels of Human,Mouse,Rat Smad1 (Phospho Ser214)
Gene Name: SMAD1 BSP1 MADH1 MADR1
Protein Name: Smad1 (Phospho Ser214)
Other Name: Mothers against decapentaplegic homolog 1;MAD homolog 1;Mothers against DPP homolog 1;JV4-1;Mad-related protein 1;SMAD family member 1;SMAD 1;Smad1;hSMAD1;Transforming growth factor-beta-signaling protein 1;BSP-1;
Organism-1: Human
Gene ID-1: 4086
SwissProt-1: Q15797
Organism-2: Mouse
Gene ID-2: 17125
SwissProt-2: P70340
Organism-3: Rat
Gene ID-3: --
SwissProt-3: P97588
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cytoplasm . Nucleus . Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4 (PubMed:15647271). Co-localizes with LEMD3 at the nucleus inner membrane (PubMed:15647271). Exported from the nucleus to the cytoplasm when dephosphorylated (By similarity). .