U-Blot® YAP (Phospho Ser397) rabbit pAb

Name: U-Blot® YAP (Phospho Ser397) rabbit pAb
SKU: WP10546
Availability: InStock

$288.00

Size:50μL

SKU: WP10546-50

Catalog No.: WP10546

Specification: 50μL/100μL

Stock: In stock

U-Blot® YAP (Phospho Ser397) rabbit pAb Learn more

Product details Specifications Q & A Education

Background：This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013],

Product Overview

Catalog No.: WP10546
SKU: WP10546-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: YAP
Reactivity: Human,Mouse,Rat
Application: WB
MW(Calculated): --
MW(Observed): 67kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: WB 1:1000-2000
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: Synthesized phosho peptide around human YAP (Ser397)
Sequence: --
Specificity: This antibody detects endogenous levels of Human Mouse Rat YAP (phospho-Ser397)
Gene Name: YAP1 YAP65
Protein Name: YAP (Ser397)
Other Name: Yorkie homolog;65 kDa Yes-associated protein;YAP65;
Organism-1: Human
Gene ID-1: 10413
SwissProt-1: P46937
Organism-2: Mouse
Gene ID-2: 22601
SwissProt-2: P46938
Organism-3: Rat
Gene ID-3: 363014
SwissProt-3: Q2EJA0
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cytoplasm . Nucleus . Both phosphorylation and cell density can regulate its subcellular localization (PubMed:18158288, PubMed:20048001). Phosphorylation sequesters it in the cytoplasm by inhibiting its translocation into the nucleus (PubMed:18158288, PubMed:20048001). At low density, predominantly nuclear and is translocated to the cytoplasm at high density (PubMed:18158288, PubMed:20048001, PubMed:25849865). PTPN14 induces translocation from the nucleus to the cytoplasm (PubMed:22525271). Localized mainly to the nucleus in the early stages of embryo development with expression becoming evident in the cytoplasm at the blastocyst and epiblast stages (By similarity). .