U-Blot® SHIP2 (Phospho Tyr986/987) rabbit pAb

Name: U-Blot® SHIP2 (Phospho Tyr986/987) rabbit pAb
SKU: WP10494
Availability: InStock

$288.00

Size:50μL

SKU: WP10494-50

Catalog No.: WP10494

Specification: 50μL/100μL

Stock: In stock

U-Blot® SHIP2 (Phospho Tyr986/987) rabbit pAb Learn more

Product details Specifications Q & A Education

Background：The protein encoded by this gene is an SH2-containing 5'-inositol phosphatase that is involved in the regulation of insulin function. The encoded protein also plays a role in the regulation of epidermal growth factor receptor turnover and actin remodelling. Additionally, this gene supports metastatic growth in breast cancer and is a valuable biomarker for breast cancer. [provided by RefSeq, Jan 2009],

Product Overview

Catalog No.: WP10494
SKU: WP10494-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: SHIP2
Reactivity: Human,Rat,Mouse,
Application: WB,ELISA,IHC
MW(Calculated): --
MW(Observed): 130kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: WB 1:500-2000;IHC 1:50-300;ELISA 1:2000-20000
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: Synthesized phosho peptide around human SHIP2 (Tyr986 and 987)
Sequence: --
Specificity: This antibody detects endogenous levels of Human SHIP2 (phospho-Tyr986 or 987)
Gene Name: INPPL1 SHIP2
Protein Name: SHIP2 (Tyr986/987)
Other Name: Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2;Inositol polyphosphate phosphatase-like protein 1;INPPL-1;Protein 51C;SH2 domain-containing inositol 5'-phosphatase 2;SH2 domain-containing inositol phosphatase 2;SHIP-2;
Organism-1: Human
Gene ID-1: 3636
SwissProt-1: O15357
Organism-2: Mouse
Gene ID-2: 16332
SwissProt-2: Q6P549
Organism-3: Rat
Gene ID-3: 65038
SwissProt-3: Q9WVR3
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cytoplasm, cytosol . Cytoplasm, cytoskeleton. Membrane ; Peripheral membrane protein. Cell projection, filopodium . Cell projection, lamellipodium . Nucleus . Nucleus speckle . Translocates to membrane ruffles when activated, translocation is probably due to different mechanisms depending on the stimulus and cell type. Partly translocated via its SH2 domain which mediates interaction with tyrosine phosphorylated receptors such as the FC-gamma-RIIB receptor (FCGR2B). Tyrosine phosphorylation may also participate in membrane localization. Insulin specifically stimulates its redistribution from the cytosol to the plasma membrane. Recruited to the membrane following M-CSF stimulation. In activated spreading platelets, localizes with actin at filopodia, lamellipodia and the central actin ring.