U-Blot® Rad18 (Phospho Ser403) rabbit pAb

Name: U-Blot® Rad18 (Phospho Ser403) rabbit pAb
SKU: WP10462
Availability: InStock

$288.00

Size:50μL

SKU: WP10462-50

Catalog No.: WP10462

Specification: 50μL/100μL

Stock: In stock

U-Blot® Rad18 (Phospho Ser403) rabbit pAb Learn more

Product details Specifications Q & A Education

Background：The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008],

Product Overview

Catalog No.: WP10462
SKU: WP10462-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: Rad18
Reactivity: Human,Rat,Mouse,
Application: WB,ELISA,IHC
MW(Calculated): --
MW(Observed): 56kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: WB 1:500-2000;IHC 1:50-300;ELISA 1:2000-20000
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: Synthesized phosho peptide around human Rad18 (Ser403)
Sequence: --
Specificity: This antibody detects endogenous levels of Human Rad18 (phospho-Ser403)
Gene Name: RAD18 RNF73
Protein Name: Rad18 (Ser403)
Other Name: RAD18;RNF73;E3 ubiquitin-protein ligase RAD18;Postreplication repair protein RAD18;hHR18;hRAD18;RING finger protein 73
Organism-1: Human
Gene ID-1: 56852
SwissProt-1: Q9NS91
Organism-2: Mouse
Gene ID-2: 58186
SwissProt-2: Q9QXK2
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Associates with chromatin (PubMed:25931565). Colocalizes with SLF1 in the nucleus and to centrosomes (PubMed:15632077). Relocalizes with SLF1 to nuclear foci in response to DNA damage (PubMed:22036607). Accumulates with the SLF1-SLF2 and SMC5-SMC6 complexes at replication-coupled DNA interstrand repair and DNA double-strand breaks (DSBs) sites on chromatin in a ubiquitin-dependent manner (PubMed:25931565). .