U-Blot® LRP6 (Phospho Ser1490) rabbit pAb

Name: U-Blot® LRP6 (Phospho Ser1490) rabbit pAb
SKU: WP10403
Availability: InStock

$288.00

Size:50μL

SKU: WP10403-50

Catalog No.: WP10403

Specification: 50μL/100μL

Stock: In stock

U-Blot® LRP6 (Phospho Ser1490) rabbit pAb Learn more

Product details Specifications Q & A Education

Background：This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009],

Product Overview

Catalog No.: WP10403
SKU: WP10403-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: LRP6
Reactivity: Human,Rat,Mouse,
Application: WB,IHC
MW(Calculated): --
MW(Observed): 177kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: WB 1:500-2000;IHC 1:50-300
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: Synthesized phosho peptide around human LRP6 (Ser1490)
Sequence: --
Specificity: This antibody detects endogenous levels of Human LRP6 (phospho-Ser1490)
Gene Name: LRP6
Protein Name: LRP6 (Ser1490)
Other Name: Low-density lipoprotein receptor-related protein 6;LRP-6;
Organism-1: Human
Gene ID-1: 4040
SwissProt-1: O75581
Organism-2: Mouse
Gene ID-2: 16974
SwissProt-2: O88572
Organism-3: --
Gene ID-3: --
SwissProt-3: --
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cell membrane ; Single-pass type I membrane protein. Endoplasmic reticulum . Membrane raft . On Wnt signaling, undergoes a cycle of caveolin- or clathrin-mediated endocytosis and plasma membrane location. Released from the endoplasmic reticulum on palmitoylation. Mono-ubiquitination retains it in the endoplasmic reticulum in the absence of palmitoylation. On Wnt signaling, phosphorylated, aggregates and colocalizes with AXIN1 and GSK3B at the plasma membrane in LRP6-signalsomes. Chaperoned to the plasma membrane by MESD (By similarity). .