U-Blot® DRP1 (Phospho Ser616) rabbit pAb

Name: U-Blot® DRP1 (Phospho Ser616) rabbit pAb
SKU: WP10339
Availability: InStock

$288.00

Size:50μL

SKU: WP10339-50

Catalog No.: WP10339

Specification: 50μL/100μL

Stock: In stock

U-Blot® DRP1 (Phospho Ser616) rabbit pAb Learn more

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Background：This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013],

Product Overview

Catalog No.: WP10339
SKU: WP10339-50
Category: Polyclonal antibodies
Product Type: Other
Size: 50μL/100μL
Stock Status: In stock
Available Stock: 20
Minimum Order Quantity: 1

Storage & Compliance

Storage: -15°C to -25°C/1 year(Do not lower than -25°C)
Research Use Only: Yes

Additional Specifications

Target: DRP1
Reactivity: Human,Mouse,Rat
Application: WB
MW(Calculated): --
MW(Observed): 80kD
Host Species: Rabbit
Isotype: IgG
Conjugate/Modification: Phospho
Modification site: --
Recommended Dilution Ratio: WB 1:1000-2000
Form: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Source: --
Purification: The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Purity: --
storageCondition: -15°C to -25°C/1 year(Do not lower than -25°C)
Concentration: 1 mg/ml
Clonality: Polyclonal
Clone No.: --
Immunogen: Synthesized phosho peptide around human DRP1 (Ser616)
Sequence: --
Specificity: Phospho-DRP1 (S616) Polyclonal Antibody detects endogenous levels of DRP1 protein only when phosphorylated at S616(human), S622(mouse), S635(rat)
Gene Name: DNM1L DLP1 DRP1
Protein Name: DRP1 (Ser616)
Other Name: Dynamin-1-like protein;Dnm1p/Vps1p-like protein;DVLP;Dynamin family member proline-rich carboxyl-terminal domain less;Dymple;Dynamin-like protein;Dynamin-like protein 4;Dynamin-like protein IV;HdynIV;Dynamin-related protein 1;
Organism-1: Human
Gene ID-1: 10059
SwissProt-1: O00429
Organism-2: Mouse
Gene ID-2: 74006
SwissProt-2: Q8K1M6
Organism-3: Rat
Gene ID-3: 114114
SwissProt-3: O35303
Organism-4: --
gene ID-4: --
SwissProt-4: --
Cellular Localization: Cytoplasm, cytosol. Golgi apparatus. Endomembrane system; Peripheral membrane protein. Mitochondrion outer membrane ; Peripheral membrane protein. Peroxisome. Membrane, clathrin-coated pit . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane . Mainly cytosolic. Recruited by RALA and RALBP1 to mitochondrion during mitosis (PubMed:21822277). Translocated to the mitochondrial membrane through O-GlcNAcylation and interaction with FIS1. Colocalized with MARCHF5 at mitochondrial membrane. Localizes to mitochondria at sites of division. Localizes to mitochondria following necrosis induction. Recruited to the mitochondrial outer membrane by interaction with MIEF1. Mitochondrial recruitment is inhibited by C11orf65/MFI (By similarity). Associated with peroxisomal membranes, partly recruited there by PEX11B. May also be associated with endoplasmic reticulum tubules and cytoplasmic vesicles and found to be perinuclear. In some cell types, localizes to the Golgi complex (By similarity). Binds to phospholipid membranes (By similarity). .