Product information
Background:beclin 1(BECN1) Homo sapiens This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],
Product Overview
- Catalog No.
- WM1198
- SKU
- WM1198-50
- Category
- Mouse mAbs
- Product Type
- Other
- Size
- 50μL/100μL
- Stock Status
- In stock
- Available Stock
- 20
- Minimum Order Quantity
- 1
Storage & Compliance
- Storage
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Research Use Only
- Yes
Additional Specifications
- Target
- Beclin 1
- Reactivity
- Human,Rat,Mouse,Bovine
- Application
- WB,IHC,IF
- MW(Calculated)
- --
- MW(Observed)
- 60kD
- Host Species
- Mouse
- Isotype
- --
- Conjugate/Modification
- Unmodified
- Modification site
- --
- Recommended Dilution Ratio
- WB 1:1000-2000;IHC 1:100-200;IF 1:50-200
- Form
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- Source
- --
- Purification
- The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
- Purity
- --
- storageCondition
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Concentration
- 1 mg/ml
- Clonality
- Monoclonal
- Clone No.
- 5C2
- Immunogen
- Synthetic Peptide of Beclin-1 at AA range of 110-190
- Sequence
- --
- Specificity
- Beclin-1 protein detects endogenous levels of BECN1
- Gene Name
- BECN1
- Protein Name
- BECN1
- Other Name
- BECN1
- Organism-1
- Human
- Gene ID-1
- 8678
- SwissProt-1
- Q14457
- Organism-2
- Mouse
- Gene ID-2
- --
- SwissProt-2
- O88597
- Organism-3
- Rat
- Gene ID-3
- --
- SwissProt-3
- Q91XJ1
- Organism-4
- --
- gene ID-4
- --
- SwissProt-4
- --
- Cellular Localization
- Cytoplasm . Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein . Endosome membrane ; Peripheral membrane protein . Endoplasmic reticulum membrane ; Peripheral membrane protein . Mitochondrion membrane ; Peripheral membrane protein . Endosome . Cytoplasmic vesicle, autophagosome . Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells (By similarity). .; [Beclin-1-C 35 kDa]: Mitochondrion . Nucleus . Cytoplasm .; [Beclin-1-C 37 kDa]: Mitochondrion .
01
Documents
Datasheet, COA, SDS, and protocol files can be requested from technical support.
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Storage & Handling
- Storage
- -15°C to -25°C/1 year(Do not lower than -25°C)