Product information
Background:This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008],
Product Overview
- Catalog No.
- WM1058
- SKU
- WM1058-50
- Category
- Mouse mAbs
- Product Type
- Other
- Size
- 50μL/100μL
- Stock Status
- In stock
- Available Stock
- 20
- Minimum Order Quantity
- 1
Storage & Compliance
- Storage
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Research Use Only
- Yes
Additional Specifications
- Target
- PARP
- Reactivity
- Human
- Application
- IF,WB,IHC,
- MW(Calculated)
- --
- MW(Observed)
- 116,89kD
- Host Species
- Mouse
- Isotype
- --
- Conjugate/Modification
- Unmodified
- Modification site
- --
- Recommended Dilution Ratio
- IF 1:50-200;WB 1:2000-5000;IHC 1:50-300
- Form
- PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.
- Source
- --
- Purification
- The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
- Purity
- --
- storageCondition
- -15°C to -25°C/1 year(Do not lower than -25°C)
- Concentration
- --
- Clonality
- Monoclonal
- Clone No.
- --
- Immunogen
- Synthetic Peptide of Cleaved PARP
- Sequence
- --
- Specificity
- The antibody detects endogenous pro and active PARP protein.
- Gene Name
- PARP1
- Protein Name
- Poly [ADP-ribose] polymerase 1
- Other Name
- PARP1;ADPRT;PPOL;Poly [ADP-ribose] polymerase 1;PARP-1;ADP-ribosyltransferase diphtheria toxin-like 1;ARTD1;NAD;+;ADP-ribosyltransferase 1;ADPRT 1;Poly[ADP-ribose] synthase 1
- Organism-1
- Human
- Gene ID-1
- 142
- SwissProt-1
- P09874
- Organism-2
- Mouse
- Gene ID-2
- --
- SwissProt-2
- P11103
- Organism-3
- Rat
- Gene ID-3
- 25591
- SwissProt-3
- P27008
- Organism-4
- --
- gene ID-4
- --
- SwissProt-4
- --
- Cellular Localization
- Nucleus . Nucleus, nucleolus . Chromosome . Localizes to sites of DNA damage. .
01
Documents
Datasheet, COA, SDS, and protocol files can be requested from technical support.
02
Storage & Handling
- Storage
- -15°C to -25°C/1 year(Do not lower than -25°C)