- PackSize
- 50ug/100ug
- Target
- Envelopment polyprotein, GP, Glycoprotein G1, Glycoprotein N, Gn
- Reactivity
- Rift valley fever virus (RVFV)
- Applications
- ELISA, Neutralization, in vivo
- Host Species
- Human
- Isotype
- IgG1, kappa
- Conjugate/Modification
- --
- Recommended Dilution Ratio
- --
- Composition
- 0.01M PBS pH 7.4
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
- Purification Process
- Protein A/G purified from cell culture supernatant.
- Purity
- >95% as determined by SDS-PAGE.
- storageCondition
- Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
- Clonality
- Monoclonal
- Clone Number
- VFA2775
- Immunogen
- --
- Alias
- --
- Species
- --
- Gene ID-1
- P21401
- Uniprot
- --
- Background
- Envelopment polyprotein (Gn) is a ~130 kDa protein. Structural component of the virion that interacts with glycoprotein C. It shields the hydrophobic fusion loops of the glycoprotein C, preventing premature fusion. The glycoprotein protrusions are arranged on an icosahedral lattice, with T=12 triangulation. They are able to attach the virion to the host cell receptor CD209/DC-SIGN and to promote fusion of membranes with the late endosome after endocytosis of the virion. Plays a role in the packaging of ribonucleoproteins and polymerase during virus assembly.
1. Freiberg, AN. et al. (2008) Journal of virology 82, 10341-8.
PMID: 18715915
2. Halldorsson, S. et al. (2018) Nature communications 9, 349.
PMID: 29367607
3. Lozach, PY. et al. (2011) Cell host & microbe 10, 75-88.
PMID: 21767814
4. Piper, ME. et al. (2011) PloS one 6, e18070.
PMID: 21445316
- Tissue Expression
- --
- Signaling_pathway
- --
- Research Areas
- --