- PackSize
- 50ug/100ug
- Target
- MAdCAM-1, Madcam1, Mucosal addressin cell adhesion molecule 1, mMAdCAM-1
- Reactivity
- Mouse
- Applications
- IP, WP, Block, FCM, IHC
- Host Species
- Rat
- Isotype
- IgG2a, kappa
- Conjugate/Modification
- --
- Recommended Dilution Ratio
- --
- Composition
- 0.01M PBS pH 7.4
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
- Purification Process
- Protein A/G purified from cell culture supernatant.
- Purity
- >95% as determined by SDS-PAGE.
- storageCondition
- Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
- Clonality
- Monoclonal
- Clone Number
- MECA-367
- Immunogen
- --
- Alias
- --
- Species
- --
- Gene ID-1
- Q61826
- Uniprot
- --
- Background
- Mucosal addressin cell adhesion molecule 1 (MAdCAM-1) is a ~43 kDa protein. Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both the integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Both isoform 1 and isoform 2 can adhere to integrin alpha-4/beta-7. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.
- Tissue Expression
- --
- Signaling_pathway
- --
- Research Areas
- --