- PackSize
- 50ug/100ug
- Target
- CS, CSP, Circumsporozoite protein, Circumsporozoite protein C-terminus, PfCSP
- Reactivity
- Plasmodium falciparum
- Applications
- --
- Host Species
- --
- Isotype
- --
- Conjugate/Modification
- --
- Recommended Dilution Ratio
- --
- Composition
- 0.01M PBS pH 7.4
Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
- Purification Process
- Protein A/G purified from cell culture supernatant.
- Purity
- >95% as determined by SDS-PAGE.
- storageCondition
- Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
- Clonality
- Monoclonal
- Clone Number
- MAM01
- Immunogen
- --
- Alias
- --
- Species
- --
- Gene ID-1
- Q7K740
- Uniprot
- --
- Background
- Circumsporozoite protein is a ~42 kDa protein. Essential sporozoite protein. In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands. In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes. Binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes.
1. Tan, J. et al. (2018) Nature medicine 24, 401-407.
PMID: 29554084
2. Oyen, D. et al. (2020) PLoS pathogens 16, e1008373.
PMID: 32150583
- Tissue Expression
- --
- Signaling_pathway
- --
- Research Areas
- --