U-Blot® Human IL2 Recombinant Antibody

Name: U-Blot® Human IL2 Recombinant Antibody
SKU: WE2466
Availability: InStock

$9,999.00

Size:50ug

SKU: WE2466-50

Catalog No.: WE2466

Specification: 50ug/100ug

Stock: In stock

U-Blot® Human IL2 Recombinant Antibody Learn more

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U-Blot® Human IL2 Recombinant Antibody

Product Overview

Catalog No.: WE2466
SKU: WE2466-50
Product Type: Other
Size: 50ug/100ug
Stock Status: In stock
Available Stock: 999
Minimum Order Quantity: 1

Storage & Compliance

Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Research Use Only: Yes

Additional Specifications

PackSize: 50ug/100ug
Target: Aldesleukin, IL-2, IL2, Interleukin-2, T-cell growth factor, TCGF
Reactivity: Human
Applications: ELISA, in vivo and in vitro study
Host Species: Human
Isotype: scFv-hFc
Conjugate/Modification: --
Recommended Dilution Ratio: --
Composition: 0.01M PBS pH 7.4 Please refer to the specific buffer information in the hardcopy of datasheet or the lot-specific COA.
Purification Process: Protein A/G purified from cell culture supernatant.
Purity: >95% as determined by SDS-PAGE.
storageCondition: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Clonality: Monoclonal
Clone Number: VFA2772
Immunogen: --
Alias: --
Species: --
Gene ID-1: P60568
Uniprot: --
Background: Interleukin-2 (IL2) is a ~17 kDa protein. Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. 1. Mingari, MC. et al. (1984) Nature 312, 641-3. PMID: 6438535 2. Wang, X. et al. (2005) Science (New York, N.Y.) 310, 1159-63. PMID: 16293754 3. Stauber, DJ. et al. (2006) Proceedings of the National Academy of Sciences of the United States of America 103, 2788-93. PMID: 16477002 4. Miyazaki, T. et al. (1994) Science (New York, N.Y.) 266, 1045-7. PMID: 7973659 5. Kirken, RA. et al. (1995) Cytokine 7, 689-700. PMID: 8580378 6. Osinalde, N. et al. (2015) Proteomics 15, 520-31. PMID: 25142963 7. Holbrook, NJ. et al. (1984) Proceedings of the National Academy of Sciences of the United States of America 81, 1634-8. PMID: 6608729
Tissue Expression: --
Signaling_pathway: --
Research Areas: --

Tech Support

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Documents

Datasheet, COA, SDS, and protocol files can be requested from technical support.

Storage & Handling

Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.