- PackSize
- 50ug/100ug
- Target
- IL-10
- Reactivity
- Human
- Applications
- ELISA, Functional assay, Research in vivo
- Host Species
- Mammalian Cells
- Isotype
- Vibrio cholerae L-methionyl-cholix toxin fragment fused to human IL10
- Conjugate/Modification
- --
- Recommended Dilution Ratio
- --
- Composition
- 0.01M PBS, pH 7.4.
- Purification Process
- Purified by Nickel column.
- Purity
- >95% purity as determined by SDS-PAGE.
- storageCondition
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
- Clonality
- --
- Clone Number
- --
- Immunogen
- Mammalian Cells
- Alias
- IL-10, IL10, Cytokine synthesis inhibitory factor, CSIF, Interleukin-10
- Species
- --
- Gene ID-1
- P22301
- Uniprot
- --
- Background
- Vimekofusp is a recombinant IL-10 fusion protein that targets IL10RA and IL10RB.<br>• Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRFI., PMID:2161559<br/>• Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes., PMID:1940799<br/>• Isolation of monoclonal antibodies specific for IL-4, IL-5, IL-6, and a new Th2-specific cytokine (IL-10), cytokine synthesis inhibitory factor, by using a solid phase radioimmunoadsorbent assay., PMID:2145365<br/>• Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: homology to Epstein-Barr virus open reading frame BCRFI., PMID:1847510<br/>• Interferon effects on interleukin-10 secretion. Mononuclear cell response to interleukin-10 is normal in multiple sclerosis patients., PMID:7560009<br/>• Biological properties of interleukin 10., PMID:1385707<br/>• Differential effects of IL-4 and IL-10 on IL-2-induced IFN-gamma synthesis and lymphokine-activated killer activity., PMID:1627494<br/>• IL-10, a novel growth cofactor for mature and immature T cells., PMID:2124236<br/>• Production of cytokines by mouse B cells: B lymphomas and normal B cells produce interleukin 10., PMID:1703785<br/>• Expression of interleukin-10 activity by Epstein-Barr virus protein BCRF1., PMID:2173142<br/>
- Tissue Expression
- --
- Signaling_pathway
- --
- Research Areas
- --