- PackSize
- 50ug/100ug
- Target
- CD221
- Reactivity
- Human
- Applications
- ELISA, Bioactivity: FACS, Functional assay, Research in vivo
- Host Species
- Human
- Isotype
- IgG1-kappa
- Conjugate/Modification
- --
- Recommended Dilution Ratio
- --
- Composition
- 0.01M PBS, pH 7.4.
- Purification Process
- Protein A/G purified from cell culture supernatant.
- Purity
- >95% purity as determined by SDS-PAGE.
- storageCondition
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
- Clonality
- Monoclonal
- Clone Number
- --
- Immunogen
- Mammalian Cells
- Alias
- CD221, Insulin-like growth factor 1 receptor, IGF1R, Insulin-like growth factor I receptor, IGF-I receptor
- Species
- --
- Gene ID-1
- P08069
- Uniprot
- --
- Background
- Veligrotug is an IgG1-kappa, anti-IGF1R (insulin-like growth factor 1 receptor, CD221) chimeric monoclonal antibody.<br>• Insulin-like growth factor 2 drives fibroblast-mediated tumor immunoevasion and confers resistance to immunotherapy., PMID:39545420<br/>• Insulin-like growth factor-1 receptor crosstalk with integrins, cadherins, and the tumor microenvironment: sticking points in understanding IGF1R function in cancer., PMID:37490874<br/>• Insulin-Like Growth Factor-1 (IGF-1) and Its Monitoring in Medical Diagnostic and in Sports., PMID:33557137<br/>• CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities., PMID:32238925<br/>• IGF1R is an entry receptor for respiratory syncytial virus., PMID:32494007<br/>• Endothelial insulin-like growth factor-1 signalling regulates vascular barrier function and atherogenesis., PMID:40171617<br/>• Insulin-like growth factor-1 signaling in cardiac aging., PMID:28847512<br/>• IGF1R-phosphorylated PYCR1 facilitates ELK4 transcriptional activity and sustains tumor growth under hypoxia., PMID:37777542<br/>• Expression of Insulin-Like Growth Factor Type 1 Receptor Is Linked to Inflammation in Adamantinomatous Craniopharyngioma., PMID:34915523<br/>• Insulin-Like Growth Factor 1 Receptor Drives Hepatocellular Carcinoma Growth and Invasion by Activating Stat3-Midkine-Stat3 Loop., PMID:33559791<br/>
- Tissue Expression
- --
- Signaling_pathway
- --
- Research Areas
- --