- PackSize
- 50ug/100ug
- Target
- PAUF
- Reactivity
- Human
- Applications
- ELISA, Bioactivity: FACS, Functional assay, Research in vivo
- Host Species
- Humanized
- Isotype
- IgG1-kappa
- Conjugate/Modification
- --
- Recommended Dilution Ratio
- --
- Composition
- 0.01M PBS, pH 7.4.
- Purification Process
- Protein A/G purified from cell culture supernatant.
- Purity
- >95% purity as determined by SDS-PAGE.
- storageCondition
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
- Clonality
- Monoclonal
- Clone Number
- --
- Immunogen
- Mammalian Cells
- Alias
- PAUF
- Species
- --
- Gene ID-1
- Q96DA0
- Uniprot
- --
- Background
- Ulenistamab (PBP1510) is a first-in-class hunamised IgG1 monoclonal antibody targeting pancreatic adenocarcinoma upregulated factor (PAUF). Ulenistamab can be used for pancreatic cancer (PC) research.<br>• PAUF Induces Migration of Human Pancreatic Cancer Cells Exclusively via the TLR4/MyD88/NF-κB Signaling Pathway., PMID:36232715<br/>• PAUF as a Target for Treatment of High PAUF-Expressing Ovarian Cancer., PMID:35600865<br/>• PAUF/ZG16B promotes colorectal cancer progression through alterations of the mitotic functions and the Wnt/β-catenin pathway., PMID:31095674<br/>• Direct trafficking pathways from the Golgi apparatus to the plasma membrane., PMID:32317144<br/>• Sorting secretory proteins., PMID:37997893<br/>• PAUF promotes adhesiveness of pancreatic cancer cells by modulating focal adhesion kinase., PMID:21464589<br/>• PAUF functions in the metastasis of human pancreatic cancer cells and upregulates CXCR4 expression., PMID:19784070<br/>• TGF-β-Induced PAUF Plays a Pivotal Role in the Migration and Invasion of Human Pancreatic Ductal Adenocarcinoma Cell Line Panc-1., PMID:39518973<br/>• A PAUF-neutralizing antibody targets both carcinoma and endothelial cells to impede pancreatic tumor progression and metastasis., PMID:25450371<br/>• Pancreatic Adenocarcinoma Up-Regulated Factor (PAUF) Transforms Human Monocytes into Alternative M2 Macrophages with Immunosuppressive Action., PMID:39519098<br/>
- Tissue Expression
- --
- Signaling_pathway
- --
- Research Areas
- --