U-Blot® Research Grade Tilvestamab

Name: U-Blot® Research Grade Tilvestamab
SKU: WA3662
Availability: InStock

$9,999.00

Size:50ug

SKU: WA3662-50

Catalog No.: WA3662

Specification: 50ug/100ug

Stock: In stock

Product details, specifications, documents, and related products are available from the catalog record. Learn more

Product details Specifications Q & A Education

Product details, specifications, documents, and related products are available from the catalog record.

Product Overview

Catalog No.: WA3662
SKU: WA3662-50
Category: Biosimilar Antibodies
Product Type: Other
Size: 50ug/100ug
Stock Status: In stock
Available Stock: 999
Minimum Order Quantity: 1

Storage & Compliance

Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Research Use Only: Yes

Additional Specifications

PackSize: 50ug/100ug
Target: UFO
Reactivity: Human
Applications: ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host Species: Humanized
Isotype: IgG1-kappa
Conjugate/Modification: --
Recommended Dilution Ratio: --
Composition: 0.01M PBS, pH 7.4.
Purification Process: Protein A/G purified from cell culture supernatant.
Purity: >95% purity as determined by SDS-PAGE.
storageCondition: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Clonality: Monoclonal
Clone Number: --
Immunogen: Mammalian Cells
Alias: UFO, AXL oncogene, Tyrosine-protein kinase receptor UFO, AXL
Species: --
Gene ID-1: P30530
Uniprot: --
Background: Mecbotamab is a humanized IgG1-κ antibody targeting to AXL receptor tyrosine kinase (AXL). Mecbotamab can serves as a conditionally active biologic (CAB), which can be conjugated with MMAE via a cleavable linker, to form ADC Mecbotamab vedotin (BA3011). • Intracellular signaling of the Ufo/Axl receptor tyrosine kinase is mediated mainly by a multi-substrate docking-site., PMID:9178760 • Recent progress on the role of Axl, a receptor tyrosine kinase, in malignant transformation of myeloid leukemias., PMID:9130617 • Identification of AXL as a co-receptor for human parvovirus B19 infection of human erythroid progenitors., PMID:36630517 • The TAM family: phosphatidylserine sensing receptor tyrosine kinases gone awry in cancer., PMID:25568918 • Targeting rapid TKI-induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia., PMID:39395205 • Cloning of the cDNA for a novel receptor tyrosine kinase, Sky, predominantly expressed in brain., PMID:8108112 • Serum AXL is a potential molecular marker for predicting COVID-19 progression., PMID:38799467 • Clinical significance of AXL kinase family in gastric cancer., PMID:12168903 • Quantitative phosphoproteomics revealed interplay between Syk and Lyn in the resistance to nilotinib in chronic myeloid leukemia cells., PMID:21730355 • The genomic structure of the human UFO receptor., PMID:8381225
Tissue Expression: --
Signaling_pathway: --
Research Areas: --

Tech Support

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Documents

Datasheet, COA, SDS, and protocol files can be requested from technical support.

Storage & Handling

Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.