U-Blot® Research Grade Tenecteplase

Name: U-Blot® Research Grade Tenecteplase
SKU: WA3637
Availability: InStock

$9,999.00

Size:50ug

SKU: WA3637-50

Catalog No.: WA3637

Specification: 50ug/100ug

Stock: In stock

Product details, specifications, documents, and related products are available from the catalog record. Learn more

Product details Specifications Q & A Education

Product details, specifications, documents, and related products are available from the catalog record.

Product Overview

Catalog No.: WA3637
SKU: WA3637-50
Category: Biosimilar Antibodies
Product Type: Other
Size: 50ug/100ug
Stock Status: In stock
Available Stock: 999
Minimum Order Quantity: 1

Storage & Compliance

Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Research Use Only: Yes

Additional Specifications

PackSize: 50ug/100ug
Target: t-plasminogen activator
Reactivity: Human
Applications: ELISA, Functional assay, Research in vivo
Host Species: Mammalian Cells
Isotype: --
Conjugate/Modification: --
Recommended Dilution Ratio: --
Composition: 315mM Arginine, pH7.3, 173mM H3PO4, 0.043% Tween20.
Purification Process: Purified by ion exchange chromatography.
Purity: >95% purity as determined by SDS-PAGE.
storageCondition: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Clonality: --
Clone Number: --
Immunogen: Mammalian Cells
Alias: t-plasminogen activator, tPA, t-PA, Reteplase, Tissue-type plasminogen activator, Alteplase, PLAT
Species: --
Gene ID-1: P00750
Uniprot: --
Background: Tenecteplase, sold under the brand names Tnkase among others, is an enzyme used as a thrombolytic drug.Tenecteplase is a tissue plasminogen activator (tPA) produced by recombinant DNA technology using an established mammalian cell line (Chinese hamster ovary cells). Tenecteplase is a 527 amino acid glycoprotein developed by introducing the following modifications to the complementary DNA for natural human tPA: a substitution of threonine 103 with asparagine, and a substitution of asparagine 117 with glutamine, both within the kringle 1 domain, and a tetra-alanine substitution at amino acids 296–299 in the protease domain.Tenecteplase is a recombinant fibrin-specific plasminogen activator that is derived from native t-PA by modifications at three sites of the protein structure. It binds to the fibrin component of the thrombus (blood clot) and selectively converts thrombus-bound plasminogen to plasmin, which degrades the fibrin matrix of the thrombus. Tenecteplase has a higher fibrin specificity and greater resistance to inactivation by its endogenous inhibitor (PAI-1) compared to native t-PA.Tenecteplase was approved for medical use in the United States in June 2000.Medical usesTenecteplase is indicated to reduce the risk of death associated with acute ST elevation myocardial infarction.PharmacokineticsDistribution: approximates plasma volumeMetabolism: Primarily hepaticHalf-life elimination: Biphasic: Initial: 20–24 minutes; Terminal: 90–130 minutesExcretion: Clearance: Plasma: 99–119 mL/minuteGalleryResearchResearchers at Newcastle University in Australia say they have had a significant breakthrough in treating stroke patients using the commonly used drug. The findings were published in the New England Medical Journal. Though safety has been established through previous clinical trials, there is ongoing debate about whether this is an effective treatment for ischemic stroke, and significant ongoing discussion between emergency physicians, neurologists and pharmacists about whether this treatment should be used for that indication.The American Heart Association/American Stroke Association 2019 update to the 2018 guidelines for the Early Management of Acute Ischemic Stroke supports considering tenecteplase over alteplase in patients without contraindication to intravenous thrombolytics.References== Further reading ==<br>
Tissue Expression: --
Signaling_pathway: --
Research Areas: --

Tech Support

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Documents

Datasheet, COA, SDS, and protocol files can be requested from technical support.

Storage & Handling

Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.