- PackSize
- 50ug/100ug
- Target
- CD134
- Reactivity
- Human
- Applications
- ELISA, Bioactivity: FACS, Functional assay, Research in vivo
- Host Species
- Humanized
- Isotype
- IgG1-kappa
- Conjugate/Modification
- --
- Recommended Dilution Ratio
- --
- Composition
- 0.01M PBS, pH 7.4.
- Purification Process
- Protein A/G purified from cell culture supernatant.
- Purity
- >95% purity as determined by SDS-PAGE.
- storageCondition
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
- Clonality
- Monoclonal
- Clone Number
- --
- Immunogen
- Mammalian Cells
- Alias
- ACT35 antigen, TXGP1L, TAX transcriptionally-activated glycoprotein 1 receptor, Tumor necrosis factor receptor superfamily member 4, TNFRSF4, OX40L receptor, CD134
- Species
- --
- Gene ID-1
- P43489
- Uniprot
- --
- Background
- Ivuxolimab (PF-04518600) is an activating monoclonal antibody to TNFRSF4 (OX40, CD134), which mimics the binding of the ligand, TNFSF4 (OX40L, CD252), to stimulate proliferation of T-cells and enhance an anti-tumor response<br>• Targeting co-stimulatory molecules in autoimmune disease., PMID:32939077<br/>• OX40 in the Pathogenesis of Atopic Dermatitis-A New Therapeutic Target., PMID:38236520<br/>• The role of OX40 ligand/OX40 axis signalling in atopic dermatitis., PMID:38836560<br/>• Target-conditioned diffusion generates potent TNFR superfamily antagonists and agonists., PMID:39636970<br/>• An OX-Tra'Ordinary Tale: The Role of OX40 and OX40L in Atopic Dermatitis., PMID:38607026<br/>• Entry of betaherpesviruses., PMID:31439151<br/>• OX40 (CD134) and OX40L., PMID:19760068<br/>• Research progress in OX40/OX40L in allergic diseases., PMID:39404736<br/>• The OX40-TRAF6 axis promotes CTLA-4 degradation to augment antitumor CD8<sup>+</sup> T-cell immunity., PMID:37932534<br/>• The role of tumor necrosis factor receptor superfamily member 4 (TNFRSF4) gene expression in diagnosis and prognosis of acute myeloid leukemia., PMID:34453673<br/>
- Tissue Expression
- --
- Signaling_pathway
- --
- Research Areas
- --