- PackSize
- 50ug/100ug
- Target
- CD52
- Reactivity
- Dog
- Applications
- ELISA, Bioactivity: FACS, Functional assay, Research in vivo
- Host Species
- Caninized
- Isotype
- IgG2-kappa-lambda
- Conjugate/Modification
- --
- Recommended Dilution Ratio
- --
- Composition
- 0.01M PBS, pH 7.4.
- Purification Process
- Protein A/G purified from cell culture supernatant.
- Purity
- >95% purity as determined by SDS-PAGE.
- storageCondition
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
- Clonality
- Monoclonal
- Clone Number
- --
- Immunogen
- Mammalian Cells
- Alias
- CD52
- Species
- --
- Gene ID-1
- Q28896
- Uniprot
- --
- Background
- Tamtuvetmab (AT-005) is a caninised blontuvetmab against CD52. Tamtuvetmab increases progression-free survival (PFS), exhibits in vivo efficacy in dogs with naïve T-cell lymphoma (LSA). Tamtuvetmab has been approved by veterinary.<br>• CD52 antigen--a review., PMID:11257744<br/>• Anti-CD52 Therapy for Multiple Sclerosis: An Update in the COVID Era., PMID:34268256<br/>• CD52 mRNA expression predicts prognosis and response to immune checkpoint blockade in melanoma., PMID:37975535<br/>• ESCMID Study Group for Infections in Compromised Hosts (ESGICH) Consensus Document on the safety of targeted and biological therapies: an infectious diseases perspective (Agents targeting lymphoid cells surface antigens [I]: CD19, CD20 and CD52)., PMID:29447988<br/>• Surface CD52, CD84, and PTGER2 mark mature PMN-MDSCs from cancer patients and G-CSF-treated donors., PMID:38242120<br/>• The immunological function of CD52 and its targeting in organ transplantation., PMID:28283679<br/>• CD52 (CAMPATH1)., PMID:11860230<br/>• Preoperative CD52 Level Predicts Graft Survival following Kidney Transplantation., PMID:39281063<br/>• CD52 and OXPHOS-potential targets in ibrutinib-treated mantle cell lymphoma., PMID:36587029<br/>• CD52-targeted depletion by Alemtuzumab ameliorates allergic airway hyperreactivity and lung inflammation., PMID:33731828<br/>
- Tissue Expression
- --
- Signaling_pathway
- --
- Research Areas
- --