U-Blot® Research Grade Taldefgrobep alfa

Name: U-Blot® Research Grade Taldefgrobep alfa
SKU: WA3603
Availability: InStock

$9,999.00

Size:50ug

SKU: WA3603-50

Catalog No.: WA3603

Specification: 50ug/100ug

Stock: In stock

Product details, specifications, documents, and related products are available from the catalog record. Learn more

Product details Specifications Q & A Education

Product details, specifications, documents, and related products are available from the catalog record.

Product Overview

Catalog No.: WA3603
SKU: WA3603-50
Category: Biosimilar Antibodies
Product Type: Other
Size: 50ug/100ug
Stock Status: In stock
Available Stock: 999
Minimum Order Quantity: 1

Storage & Compliance

Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Research Use Only: Yes

Additional Specifications

PackSize: 50ug/100ug
Target: GDF-8
Reactivity: Human
Applications: ELISA, Functional assay, Research in vivo
Host Species: Human
Isotype: Fusion - IGHG1 Fc (Fragment constant) - [peptidyl linker - Alternative to antigen receptors (domain scaffold: FN1 F10, fibronectin domain F10)]2
Conjugate/Modification: --
Recommended Dilution Ratio: --
Composition: 0.01M PBS, pH 7.4.
Purification Process: Protein A/G purified from cell culture supernatant.
Purity: >95% purity as determined by SDS-PAGE.
storageCondition: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Clonality: --
Clone Number: --
Immunogen: Mammalian Cells
Alias: GDF-8, GDF8, MSTN, Myostatin, Growth/differentiation factor 8
Species: --
Gene ID-1: O14793
Uniprot: --
Background: Ramatercept (ACE-031) is a soluble ActRIIB receptor and can be used as a soluble activin receptor 2 (ACVR2) antagonist. Ramatercept inhibits the signal pathway of muscle growth inhibition and has potential application in muscle atrophy. • Targeting the myostatin signaling pathway to treat muscle loss and metabolic dysfunction., PMID:33938454 • Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member., PMID:9139826 • GDF8 inhibition enhances musculoskeletal recovery and mitigates posttraumatic osteoarthritis following joint injury., PMID:38019905 • Growth differentiation factor 8 down-regulates pentraxin 3 in human granulosa cells., PMID:25641196 • Growth differentiation factor myostatin regulates epithelial-mesenchymal transition genes and enhances invasion by increasing serine protease inhibitors E1 and E2 in human trophoblast cells., PMID:37738042 • Growth differentiation factor 8 induces SKOV3 ovarian cancer cell migration and E-cadherin down-regulation., PMID:27481097 • Circulating Growth Differentiation Factor 11/8 Levels Decline With Age., PMID:26489925 • Crystal structure of the WFIKKN2 follistatin domain reveals insight into how it inhibits growth differentiation factor 8 (GDF8) and GDF11., PMID:30814254 • Effects of growth differentiation factor 8 on steroidogenesis in human granulosa-lutein cells., PMID:26607022 • Molecular characterization of latent GDF8 reveals mechanisms of activation., PMID:29348202
Tissue Expression: --
Signaling_pathway: --
Research Areas: --

Tech Support

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Documents

Datasheet, COA, SDS, and protocol files can be requested from technical support.

Storage & Handling

Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.