- PackSize
- 50ug/100ug
- Target
- EDB
- Reactivity
- Human
- Applications
- ELISA, Bioactivity: FACS, Functional assay, Research in vivo
- Host Species
- Human
- Isotype
- [scFv-heavy-kappa-TNF(tumornecrosisfactor(TNF)superfamilymember2, TNFSF2, TNF-alpha, TNFA)]-trimer
- Conjugate/Modification
- --
- Recommended Dilution Ratio
- --
- Composition
- 0.01M PBS, pH 7.4.
- Purification Process
- Protein A/G purified from cell culture supernatant.
- Purity
- >95% purity as determined by SDS-PAGE.
- storageCondition
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
- Clonality
- Monoclonal
- Clone Number
- --
- Immunogen
- Mammalian Cells
- Alias
- EDB, EDB-FN
- Species
- --
- Gene ID-1
- P02751-7
- Uniprot
- --
- Background
- Onfekafusp alfa (L19TNF) is a homotrimer that forms from engineered peptides for the L19 antibody in scFv format fused to human TNF. Onfekafusp alfa can be used for malignant glioma research.<br>• EDB-FN targeted probes for the surgical navigation, radionuclide imaging, and therapy of thyroid cancer., PMID:36807768<br/>• EDB-FN Targeted Peptide-Drug Conjugates for Use against Prostate Cancer., PMID:31277465<br/>• EDB-FN-targeted probes for near infrared fluorescent imaging and positron emission tomography imaging of breast cancer in mice., PMID:39333775<br/>• Anti-Extra Domain B Splice Variant of Fibronectin Antibody-Drug Conjugate Eliminates Tumors with Enhanced Efficacy When Combined with Checkpoint Blockade., PMID:35793468<br/>• Evaluation of EDB Fibronectin in Plasma, Patient-Derived Xenograft Formalin-Fixed Paraffin-Embedded and Fresh Frozen Tumor Tissues Using Immunoaffinity LC-MS/MS., PMID:36049057<br/>• EDB Fibronectin-Specific SPECT Probe <sup>99m</sup>Tc-HYNIC-ZD2 for Breast Cancer Detection., PMID:30023665<br/>• Tenascin-C: Form versus function., PMID:25482829<br/>• EDB Fibronectin Specific Peptide for Prostate Cancer Targeting., PMID:25848940<br/>• EDB fibronectin and angiogenesis -- a novel mechanistic pathway., PMID:16308732<br/>• RT-PCR detection of fibronectin EDA+ and EDB+ mRNA isoforms: molecular markers for hepatocellular carcinoma., PMID:7509777<br/>
- Tissue Expression
- --
- Signaling_pathway
- --
- Research Areas
- --