- PackSize
- 50ug/100ug
- Target
- IL1F1
- Reactivity
- Human
- Applications
- ELISA, Bioactivity: FACS, Functional assay, Research in vivo
- Host Species
- Humanized
- Isotype
- IgG1-kappa (DVD-Ig)
- Conjugate/Modification
- --
- Recommended Dilution Ratio
- --
- Composition
- 0.01M PBS, pH 7.4.
- Purification Process
- Protein A/G purified from cell culture supernatant.
- Purity
- >95% as determined by SDS-PAGE.
- storageCondition
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
- Clonality
- Monoclonal
- Clone Number
- --
- Immunogen
- Mammalian Cells
- Alias
- IL1F1, Interleukin-1 alpha, IL1A, Hematopoietin-1, IL-1 alpha, Interleukin-1 beta, IL1B, Catabolin, IL1F2, IL-1 beta
- Species
- --
- Gene ID-1
- P01583 & P01584
- Uniprot
- --
- Background
- Goflikicept (RPH 104) is a fusion protein that selectively binds and inactivates both circulating IL-1β and IL-1α. Goflikicept has the potential for the research of ST-segment elevation myocardial infarction (STEMI).<br>• Bacterial Endotoxin Activates the Coagulation Cascade through Gasdermin D-Dependent Phosphatidylserine Exposure., PMID:31836429<br/>• Phase 3 Trial of Interleukin-1 Trap Rilonacept in Recurrent Pericarditis., PMID:33200890<br/>• Deconvolution of monocyte responses in inflammatory bowel disease reveals an IL-1 cytokine network that regulates IL-23 in genetic and acquired IL-10 resistance., PMID:33037057<br/>• The interactions between interleukin-1 family genes: IL1A, IL1B, IL1RN, and obesity parameters., PMID:35139823<br/>• Targeting IL-1β in the Treatment of Atherosclerosis., PMID:33362770<br/>• IL-1 family cytokines in cardiovascular disease., PMID:29198612<br/>• Potential of cannabidiol as acne and acne scar treatment: novel insights into molecular pathways of pathophysiological factors., PMID:38904694<br/>• IL1A and IL1B gene polymorphisms and keratoconus susceptibility: evidence from an updated meta-analysis., PMID:33978542<br/>• Association between the IL-1A, IL-1B and IL-1R polymorphisms and lymphoma., PMID:34159887<br/>• Roles of IL-1 in Cancer: From Tumor Progression to Resistance to Targeted Therapies., PMID:32825489<br/>
- Tissue Expression
- --
- Signaling_pathway
- --
- Research Areas
- --