- PackSize
- 50ug/100ug
- Target
- lysobisphosphatidic acid
- Reactivity
- General
- Applications
- ELISA, Bioactivity: FACS, Functional assay, Research in vivo
- Host Species
- Human
- Isotype
- IgG1-kappa
- Conjugate/Modification
- --
- Recommended Dilution Ratio
- --
- Composition
- 0.01M PBS, pH 7.4.
- Purification Process
- Protein A/G purified from cell culture supernatant.
- Purity
- >95% purity as determined by SDS-PAGE.
- storageCondition
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
- Clonality
- Monoclonal
- Clone Number
- --
- Immunogen
- Mammalian Cells
- Alias
- lysobisphosphatidic acid, LBPA, LPA
- Species
- --
- Gene ID-1
- CAS: 1246303-12-7
- Uniprot
- --
- Background
- This humanized antibody LT3015 is generated from the high-affinity, specific anti-LPA mouse mAb LT3000, also called Lpathomab. The target of the antibody lysophosphatidic acid is a bioactive lipid mediating multiple cellular responses, and it's involved in the establishment and progression of cancer by providing a pro-growth tumor microenvironment and promoting angiogenesis. The EC₅₀ of the humanized antibody to 12:0 (lauroyl) LPA was determined to be 75.6 ng/mL by ELISA.<br>• Did mitophagy follow the origin of mitochondria?, PMID:38361280<br/>• Brown recluse spider (Loxosceles reclusa) venom phospholipase D (PLD) generates lysophosphatidic acid (LPA)., PMID:15926888<br/>
- Tissue Expression
- --
- Signaling_pathway
- --
- Research Areas
- --