U-Blot® Research Grade Latozinemab

Name: U-Blot® Research Grade Latozinemab
SKU: WA3049
Availability: InStock

$9,999.00

Size:50ug

SKU: WA3049-50

Catalog No.: WA3049

Specification: 50ug/100ug

Stock: In stock

Product details, specifications, documents, and related products are available from the catalog record. Learn more

Product details Specifications Q & A Education

Product details, specifications, documents, and related products are available from the catalog record.

Product Overview

Catalog No.: WA3049
SKU: WA3049-50
Category: Biosimilar Antibodies
Product Type: Other
Size: 50ug/100ug
Stock Status: In stock
Available Stock: 999
Minimum Order Quantity: 1

Storage & Compliance

Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Research Use Only: Yes

Additional Specifications

PackSize: 50ug/100ug
Target: Neurotensin receptor 3
Reactivity: Human
Applications: ELISA, Bioactivity: FACS, Functional assay, Research in vivo
Host Species: Human
Isotype: IgG1-Kappa
Conjugate/Modification: --
Recommended Dilution Ratio: --
Composition: 0.01M PBS, pH 7.4.
Purification Process: Protein A/G purified from cell culture supernatant.
Purity: >95% purity as determined by SDS-PAGE.
storageCondition: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
Clonality: Monoclonal
Clone Number: --
Immunogen: Mammalian Cells
Alias: Neurotensin receptor 3, Gp95, Glycoprotein 95, Sortilin, 100 kDa NT receptor, NTR3, SORT1, NT3
Species: --
Gene ID-1: Q99523
Uniprot: --
Background: Latozinemab (AL001) is a recombinant human anti-Sortilin monoclonal antibody. Latozinemab effectively binds Sortilin with a high affinity and blocks the interaction between progranulin protein (PGRN) and Sortilin receptor. Latozinemab has the potential for progranulin gene (GRN) mutations causative of Frontotemporal dementia (FTD) (FTD-GRN) research. • The 100-kDa neurotensin receptor is gp95/sortilin, a non-G-protein-coupled receptor., PMID:9756851 • Sortilin is dispensable for secondary injury processes following traumatic brain injury in mice., PMID:39170542 • Neurotrophins and their involvement in digestive cancers., PMID:30741921 • Sortilin Modulates Schwann Cell Signaling and Remak Bundle Regeneration Following Nerve Injury., PMID:35634462 • Peptides other than the neurotrophins that can be cleaved from proneurotrophins: a neglected story., PMID:17917853 • The Neurotrophin Receptor TrkC as a Novel Molecular Target of the Antineuroblastoma Action of Valproic Acid., PMID:34360553 • Proneurotrophin-3 may induce Sortilin-dependent death in inner ear neurons., PMID:21261755 • Neurotrophins and their receptors in early development of the mammalian nervous system., PMID:21196952 • Proneurotrophin-3 is a neuronal apoptotic ligand: evidence for retrograde-directed cell killing., PMID:19940174
Tissue Expression: --
Signaling_pathway: --
Research Areas: --

Tech Support

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Documents

Datasheet, COA, SDS, and protocol files can be requested from technical support.

Storage & Handling

Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.