- PackSize
- 50ug/100ug
- Target
- Emfilermin
- Reactivity
- Human
- Applications
- ELISA, Bioactivity: FACS, Functional assay, Research in vivo
- Host Species
- Human
- Isotype
- IgG1-kappa
- Conjugate/Modification
- --
- Recommended Dilution Ratio
- --
- Composition
- 0.01M PBS, pH 7.4.
- Purification Process
- Protein A/G purified from cell culture supernatant.
- Purity
- >95% purity as determined by SDS-PAGE.
- storageCondition
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
- Clonality
- Monoclonal
- Clone Number
- --
- Immunogen
- Mammalian Cells
- Alias
- Emfilermin, D factor, HILDA, LIF, MLPLI, Melanoma-derived LPL inhibitor, Leukemia inhibitory factor, Differentiation-stimulating factor
- Species
- --
- Gene ID-1
- P15018
- Uniprot
- --
- Background
- Falbikitug is a humanized immunoglobulin G1-kappa, anti-LIF monoclonal antibody. Falbikitug is an antineoplastic.<br>• Leukemia inhibitory factor (LIF)., PMID:26187859<br/>• Biomolecular Markers of Recurrent Implantation Failure-A Review., PMID:34576245<br/>• Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring., PMID:30996350<br/>• Augmentative effects of leukemia inhibitory factor reveal a critical role for TYK2 signaling in vascular calcification., PMID:39084258<br/>• Nephron induction., PMID:12386301<br/>• p53 and reproduction., PMID:29307398<br/>• A peptide derived from the CD loop-D helix region of ciliary neurotrophic factor (CNTF) induces neuronal differentiation and survival by binding to the leukemia inhibitory factor (LIF) receptor and common cytokine receptor chain gp130., PMID:22000729<br/>• Therapeutic Targeting of LIF Overcomes Macrophage-mediated Immunosuppression of the Local Tumor Microenvironment., PMID:36441800<br/>• TGF-β-driven LIF expression influences neutrophil extracellular traps (NETs) and contributes to peritoneal metastasis in gastric cancer., PMID:38490994<br/>• Super-Enhancer Driven LIF/LIFR-STAT3-SOX2 Regulatory Feedback Loop Promotes Cancer Stemness in Head and Neck Squamous Cell Carcinoma., PMID:39206755<br/>
- Tissue Expression
- --
- Signaling_pathway
- --
- Research Areas
- --