- PackSize
- 50ug/100ug
- Target
- CD54
- Reactivity
- Human
- Applications
- ELISA, Bioactivity: FACS, Functional assay, Research in vivo
- Host Species
- Mouse
- Isotype
- IgG2a-nd
- Conjugate/Modification
- --
- Recommended Dilution Ratio
- --
- Composition
- 0.01M PBS, pH 7.4.
- Purification Process
- Protein A/G purified from cell culture supernatant.
- Purity
- >95% purity as determined by SDS-PAGE.
- storageCondition
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
- Clonality
- Monoclonal
- Clone Number
- --
- Immunogen
- Mammalian Cells
- Alias
- ICAM1, Major group rhinovirus receptor, CD54, ICAM-1, Intercellular adhesion molecule 1
- Species
- --
- Gene ID-1
- P05362
- Uniprot
- --
- Background
- Bersanlimab (BI-505) is a fully human monoclonal antibody that targets intercellular adhesion molecule-1 (ICAM-1 or CD54). Bersanlimab has anticancer effects.<br>• Intercellular adhesion molecule-1 (ICAM-1): From molecular functions to clinical applications in cancer investigation., PMID:39317271<br/>• Quercetin inhibits TNF-α induced HUVECs apoptosis and inflammation via downregulating NF-kB and AP-1 signaling pathway in vitro., PMID:32957369<br/>• ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer., PMID:34381029<br/>• The Roles of Lipoprotein in Psoriasis., PMID:32013194<br/>• Islet beta-cells and intercellular adhesion molecule-1 (ICAM-1): Integrating immune responses that influence autoimmunity and graft rejection., PMID:37619906<br/>• Genetic Variation in Intercellular Adhesion Molecule-1 (ICAM-1) and Diastolic Heart Failure in the Black Population in the United States., PMID:37062471<br/>• Systematic pan-cancer analysis insights into ICAM1 as an immunological and prognostic biomarker., PMID:38979944<br/>• <i>Fusobacterium nucleatum</i> promotes colorectal cancer cells adhesion to endothelial cells and facilitates extravasation and metastasis by inducing ALPK1/NF-κB/ICAM1 axis., PMID:35220887<br/>• Gene regulation of intracellular adhesion molecule-1 (ICAM-1): A molecule with multiple functions., PMID:34715236<br/>• Intercellular adhesion molecule-1 suppresses TMZ chemosensitivity in acquired TMZ-resistant gliomas by increasing assembly of ABCB1 on the membrane., PMID:38924997<br/>
- Tissue Expression
- --
- Signaling_pathway
- --
- Research Areas
- --