- PackSize
- 50ug/100ug
- Target
- FGB
- Reactivity
- Human
- Applications
- ELISA, Bioactivity: FACS, Functional assay, Research in vivo
- Host Species
- Mouse
- Isotype
- IgG1-kappa
- Conjugate/Modification
- --
- Recommended Dilution Ratio
- --
- Composition
- 0.01M PBS, pH 7.4.
- Purification Process
- Protein A/G purified from cell culture supernatant.
- Purity
- >95% purity as determined by SDS-PAGE.
- storageCondition
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
- Clonality
- Monoclonal
- Clone Number
- --
- Immunogen
- Mammalian Cells
- Alias
- FGB, Fibrinogen beta chain
- Species
- --
- Gene ID-1
- P02675
- Uniprot
- --
- Background
- Indium (111In) biciromab (INN, trade name FibriScint, developed by Centocor) was a drug targeting fibrin, a protein involved in the clotting of blood. It was the Fab' fragment of a mouse monoclonal antibody labelled with the radioisotope indium-111 for the diagnosis of thromboembolism, but was withdrawn during clinical trials.<br>• A novel deletion in the fibrinogen beta chain (FGB) gene causing hypofibrinogenemia., PMID:31841708<br/>• A Novel Nonsense Mutation in <i>FGB</i> (c.1421G>A; p.Trp474Ter) in the Beta Chain of Fibrinogen Causing Hypofibrinogenemia with Bleeding Phenotype., PMID:33322159<br/>• Fibrinogen β chain and FXIII polymorphisms affect fibrin clot properties in acute pulmonary embolism., PMID:34783023<br/>• Genetic Variants in the <i>FGB</i> and <i>FGG</i> Genes Mapping in the Beta and Gamma Nodules of the Fibrinogen Molecule in Congenital Quantitative Fibrinogen Disorders Associated with a Thrombotic Phenotype., PMID:32610551<br/>• Fibrinogen beta chain may be a potential predict biomarker for pre-eclampsia: A preliminary study., PMID:36566955<br/>• Quantitative Proteomic Approach Targeted to Fibrinogen β Chain in Tissue Gastric Carcinoma., PMID:29518939<br/>• The β-Chain Mutation p.Arg17Stop Impairs Fibrinogen Synthesis and Secretion: A Nonsense Mutation Associated With Hypofibrinogenemia., PMID:39665495<br/>• Fibrinogen beta-chain -C148T polymorphism is associated with increased fibrinogen, C-reactive protein, and interleukin-6 in patients undergoing coronary artery bypass grafting., PMID:21499712<br/>• Investigating Association of rs5918 Human Platelets Antigen 1 and rs1800790 Fibrinogen β Chain as Critical Players with Recurrent Pregnancy Loss., PMID:30384452<br/>• [Relationship between fibrinogen B beta gene FGB -455G/A polymorphism and atherosclerotic cerebral infarction]., PMID:15300640<br/>
- Tissue Expression
- --
- Signaling_pathway
- --
- Research Areas
- --