- PackSize
- 50ug/100ug
- Target
- SAA
- Reactivity
- Human
- Applications
- ELISA, Bioactivity: FACS, Functional assay, Research in vivo
- Host Species
- Chimeric
- Isotype
- IgG1-kappa
- Conjugate/Modification
- --
- Recommended Dilution Ratio
- --
- Composition
- 0.01M PBS, pH 7.4.
- Purification Process
- Protein A/G purified from cell culture supernatant.
- Purity
- >95% purity as determined by SDS-PAGE.
- storageCondition
- Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C for short-term storage (1-2 weeks). Store at -20°C for up to 12 months. For long-term storage, store at -80°C.
- Clonality
- Monoclonal
- Clone Number
- --
- Immunogen
- Mammalian Cells
- Alias
- SAA, Serum amyloid A-1 protein, SAA1, Amyloid fibril protein AA
- Species
- --
- Gene ID-1
- P0DJI8
- Uniprot
- --
- Background
- Anselamimab (CAEL-101) a humanized IgG1-κ anti-Amyloid fibrils antibody targeting to serum amyloid A1 (SAA1).<br>• Overexpression of serum amyloid a 1 induces depressive-like behavior in mice., PMID:27608955<br/>• Pathogenic serum amyloid A 1.1 shows a long oligomer-rich fibrillation lag phase contrary to the highly amyloidogenic non-pathogenic SAA2.2., PMID:23223242<br/>• Serum amyloid A levels are associated with polymorphic variants in the serum amyloid A 1 and 2 genes., PMID:30852808<br/>• Large-scale isotype-specific quantification of Serum amyloid A 1/2 by multiple reaction monitoring in crude sera., PMID:22300576<br/>• Increased susceptibility of serum amyloid A 1.1 to degradation by MMP-1: potential explanation for higher risk of type AA amyloidosis., PMID:18815155<br/>• Diversity and complexity of the mouse Saa1 and Saa2 genes., PMID:24521869<br/>• The role of PPAR activation during the systemic response to brain injury., PMID:25994490<br/>• Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A., PMID:20890286<br/>• Hematological and acute-phase responses to diet-induced obesity in IL-6 KO mice., PMID:21996012<br/>• Clustering of six human 11p15 gene homologs within a 500-kb interval of proximal mouse chromosome 7., PMID:7698755<br/>
- Tissue Expression
- --
- Signaling_pathway
- --
- Research Areas
- --