Sku: ddf345
11.10测试
$55.00
SKU: ddf3455
Stock: Sold out
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Product information
4453
Product Overview
- Catalog No.
- ddf3455
- SKU
- ddf3455
- Category
- CATtest
- Product Type
- Other
- Stock Status
- Sold out
- Available Stock
- 0
- Minimum Order Quantity
- 1
Biological Attributes
- Research Area
- 研究领域测试, testresearch area
Storage & Compliance
- Research Use Only
- Yes
Documents & Compliance
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Product Q&A
Technical answers curated for this product by Ucallm support.
Generalww
ww
General33
2.2 Genome & Classification
The S. suis genome is a circular chromosome of approximately 2.0–2.1 Mb. Through multilocus sequence typing (MLST), over 4,200 sequence types (STs) have been identified to date, reflecting the extremely high genetic variability of this bacterium, which complicates the development of broadly protective vaccines. S. suis produces over 70 virulence factors, several of which have been extensively studied as potential vaccine targets.
2.3 What Are S. suis Virulence Factors？
The virulence factors of S. suis primarily include:
Virulence Factor | Main Function |
Capsular polysaccharide (CPS) | The most important virulence factor; evades phagocytosis by masking immunogenic surface components; CPS expression is dynamically regulated |
Suilysin (SLY) | Secreted cholesterol-dependent cytotoxin; facilitates bacterial invasion, dissemination, and blood-brain barrier disruption |
Extracellular protein factor (EF) | Immunomodulatory protein involved in immune evasion |
Two-component system Ihk/Irr | Regulates anti-phagocytic capacity and virulence; inhibits macrophage actin polymerization via the PepO axis |
PepO (aminopeptidase) | Activates p38 and ERK1/2 pathways via TLR2, inhibiting actin polymerization and phagocytosis |
ShgH | Dual histidine/glutamine transporter; involved in nutrient acquisition, anti-phagocytosis, and biofilm modulation |
Glycosyl hydrolase GhA | Promotes bacterial adhesion, blood survival, and anti-phagocytic capacity |
STK (Ser/Thr kinase) | Regulates acid resistance and virulence via phosphorylation of FadR |
2.3.1 Dynamic Regulation of Capsular Polysaccharide (CPS)
GeneralQA1
QA223
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